Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.

Updated: 2017 Aug. 1

| Home | Kinexus | Contact | Credits

Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: SMAD4 All Species: 23.64
Human Site: T77 Identified Species: 43.33
UniProt: Q13485 Number Species: 12
    Phosphosite Substitution
    Charge Score: -0.08
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens Q13485 NP_005350.1 552 60439 T77 K C V T I Q R T L D G R L Q V
Chimpanzee Pan troglodytes XP_001155006 493 53820 I74 H P S K C V T I Q R T L D G R
Rhesus Macaque Macaca mulatta XP_001095978 493 53880 I74 H P S K C V T I Q R T L D G R
Dog Lupus familis XP_849370 552 60457 T77 K C V T I Q R T L D G R L Q V
Cat Felis silvestris
Mouse Mus musculus P97471 551 60399 T77 K C V T I Q R T L D G R L Q V
Rat Rattus norvegicus O70437 552 60451 T77 K C V T I Q R T L D G R L Q V
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001509486 552 60450 T77 K C V T I Q R T L D G R L Q V
Chicken Gallus gallus P84023 426 48233
Frog Xenopus laevis NP_001090536 549 59837 G77 T I Q R T L D G R L Q V A G R
Zebra Danio Brachydanio rerio Q9I8V2 472 53048 R53 G A M E E L E R A L S C P G Q
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster P42003 455 50486 Q36 K K L L G W K Q G D E E E K W
Honey Bee Apis mellifera XP_392838 578 62051 T101 K C V T I Q R T L D G R L Q V
Nematode Worm Caenorhab. elegans P45897 570 63351 T77 Y D F P N V P T I S T L D E A
Sea Urchin Strong. purpuratus
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 87.6 88 98.9 N.A. 98 98.7 N.A. 97.4 37.8 90.9 35.5 N.A. 36.9 66 26.4 N.A.
Protein Similarity: 100 88.7 88.9 99.2 N.A. 98.7 98.9 N.A. 98.5 51.4 94.3 50 N.A. 51 74 41.4 N.A.
P-Site Identity: 100 0 0 100 N.A. 100 100 N.A. 100 0 0 0 N.A. 13.3 100 6.6 N.A.
P-Site Similarity: 100 0 0 100 N.A. 100 100 N.A. 100 0 0 6.6 N.A. 33.3 100 20 N.A.
Percent
Protein Identity: N.A. N.A. N.A. N.A. N.A. N.A.
Protein Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Identity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 8 0 0 0 0 0 0 8 0 0 0 8 0 8 % A
% Cys: 0 47 0 0 16 0 0 0 0 0 0 8 0 0 0 % C
% Asp: 0 8 0 0 0 0 8 0 0 54 0 0 24 0 0 % D
% Glu: 0 0 0 8 8 0 8 0 0 0 8 8 8 8 0 % E
% Phe: 0 0 8 0 0 0 0 0 0 0 0 0 0 0 0 % F
% Gly: 8 0 0 0 8 0 0 8 8 0 47 0 0 31 0 % G
% His: 16 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % H
% Ile: 0 8 0 0 47 0 0 16 8 0 0 0 0 0 0 % I
% Lys: 54 8 0 16 0 0 8 0 0 0 0 0 0 8 0 % K
% Leu: 0 0 8 8 0 16 0 0 47 16 0 24 47 0 0 % L
% Met: 0 0 8 0 0 0 0 0 0 0 0 0 0 0 0 % M
% Asn: 0 0 0 0 8 0 0 0 0 0 0 0 0 0 0 % N
% Pro: 0 16 0 8 0 0 8 0 0 0 0 0 8 0 0 % P
% Gln: 0 0 8 0 0 47 0 8 16 0 8 0 0 47 8 % Q
% Arg: 0 0 0 8 0 0 47 8 8 16 0 47 0 0 24 % R
% Ser: 0 0 16 0 0 0 0 0 0 8 8 0 0 0 0 % S
% Thr: 8 0 0 47 8 0 16 54 0 0 24 0 0 0 0 % T
% Val: 0 0 47 0 0 24 0 0 0 0 0 8 0 0 47 % V
% Trp: 0 0 0 0 0 8 0 0 0 0 0 0 0 0 8 % W
% Tyr: 8 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _